Cystic fibrosis: screening laboratory handbook
This document explains the guidelines for laboratories screening newborns for cystic fibrosis (CF) in the UK.
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The handbook sets out laboratory standards and guidelines for cystic fibrosis (CF) screening in newborn babies, covering:
- the CF screening protocol
- laboratory quality and performance
- pre-analytical factors
- the immunoreactive trypsinogen (IRT) assay
- genetic analysis
- reporting and communication of results
- programme monitoring and data collection
- the background to CF screening
The handbook also includes links to screening result template letters, follow up forms, and information for parents/carers.
Contact the NHS Screening helpdesk with any queries about this publication, making sure you include its full title.
Last updated 31 May 2022 + show all updates
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GSP figures in the standard protocol section of the lab handbook have been changed from 45 µg/L to 46 µg/L for cut-off A, and 55 µg/L to 56 µg/L for cut-off B. The accompanying flowchart (figure 1) has been updated to reflect these changes.
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Reviewed and updated guidance, replacing the 2014 version.
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First published.