Guidance

Clinical Trials Regulations enforcement provisions

Information about Clinical Trials Regulations outlining expanded enforcement provisions, offences, and compliance requirements for sponsors and investigators.

Documents

Details

The amended Clinical Trials Regulations took full effect on 28 April 2026. As such, this guidance should now be considered effective and is no longer in draft.

The guidance document explains that under the amended Clinical Trials Regulations, the provisions against which an infringement notice or an offence can be raised have been expanded, primarily to reflect changes in legislation as a result of this amendment. The amendment to the Regulations also brings the ability to issue infringement notices against the same provisions which, if contravened, constitute an offence to facilitate a proportionate and pragmatic approach.

Updates to this page

Published 12 January 2026
Last updated 28 April 2026 href="#full-history">+ show all updates
  1. The amended Clinical Trials Regulations took full effect on 28 April 2026. As such, this guidance should now be considered effective and is no longer in draft.

  2. Updated to remove link to feedback questionnaire as it is now over

  3. First published.

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