Change of https://www.gov.uk/government/publications/immunoglobulin-when-to-use

Change description : 2025-08-14 09:22:00: Updated ‘Rabies and Immunoglobulin Service (RIgS)’. [Guidance and regulation]

Showing diff : 2025-06-04 13:34:38.448666818 +00:00..2025-08-14 08:22:13.435764217 +00:00

Guidance

Immunoglobulin: when to use

UK Health Security Agency's immunoglobulin handbook, providing guidance on administering immunoglobulin to prevent serious disease.

From:
UK Health Security Agency
Published
1 October 2008
Last updated
414 JuneAugust 2025 — See all updates

Applies to England

Documents

Rabies and Immunoglobulin Service (RIgS)

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General product information and how to administer immunoglobulin (issued August 2020)

Ref: GOV-16767

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Diphtheria anti-toxin: clinical guidance (issued May 2022)

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Hepatitis A immunoglobulin (issued 2024)

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Hepatitis B immunoglobulin (issued November 2023)

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Babies of hepatitis B infected mothers (issued August 2008)

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Mumps and immunoglobulin (issued October 2008)

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Rabies: Human Rabies Immunoglobulin (HRIG)

Ref: Gateway number: 2018160

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Administration of HNIG for measles post-exposure prophylaxis

Ref: GOV-16767

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Details

Human Rabies Immunoglobulin (HRIG)

Further advice about post-exposure rabies treatment, supply and administration of rabies vaccine and immunoglobulin please see guidance for rabies post-exposure prophylaxis.

Measles post-exposure prophylaxis

For guidance on the use of post-exposure prophylaxis for measles in high-risk groups please see guidance for measles post-exposure prophylaxis.

Tetanus immunoglobulin

For guidance on the treatment of tetanus cases and management of tetanus prone wounds, please see tetanus: guidance for health professionals.

Post exposure prophylaxis for chickenpox and shingles

For the latest guidance, please see the guidelines on post exposure prophylaxis (PEP) for chickenpox and shingles

Immunoglobulins are concentrated antibody preparations that provide immediate short-term protection against disease for individuals at high risk of severe disease or serious complications from the disease.

These documents contain information, indications and guidance for the use of immunoglobulin preparations for each individual disease.

Updates to this page

Published 1 October 2008
Last updated 414 JuneAugust 2025 + show all updates

  2. Added telephone contact number for Rabies and Immunoglobulin Service (RIgS).

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Update history

2025-08-19 12:16
Added new ‘Information for patients on the prevention of diseases using immunoglobulin’ publication and updated ‘Administration of HNIG for measles post-exposure prophylaxis’.

2025-08-14 09:22
Updated ‘Rabies and Immunoglobulin Service (RIgS)’.

2025-06-04 14:34
Added telephone contact number for Rabies and Immunoglobulin Service (RIgS).

2025-05-19 14:00
Updated ‘Rabies and Immunoglobulin Service (RIgS)’.

2024-11-07 15:08
Removed ‘Immunoglobulins – how and when to issue out of hours’.

2024-07-01 11:00
Added ‘Administration of HNIG for measles post-exposure prophylaxis’ and updated General product information and how to administer immunoglobulin (issued August 2020) include HNIG for measles.

2024-02-20 10:05
Added ‘Hepatitis A immunoglobulin (issued 2024)’.

2023-11-14 13:28
Updated Post-exposure for non-responders section in Hepatitis B immunoglobulin.

2022-09-26 16:26
Updated hepatitis B immunoglobulin.

2022-05-04 15:37
Updated Diphtheria anti-toxin: clinical guidance.