Change of https://www.gov.uk/government/publications/cystic-fibrosis-screening-laboratory-handbook

Change description : 2026-01-05 14:12:00: Updated cut off for GSP equipment users [Guidance and regulation]

Showing diff : 2024-12-20 15:28:51.439494184 +00:00..2026-01-05 14:13:01.014479765 +00:00

Guidance

Cystic fibrosis: screening laboratory handbook

This document explains the guidelines for laboratories screening newborns for cystic fibrosis (CF) in the UK.

From:
NHS England
Published
1 February 2014
Last updated
205 DecemberJanuary 20242026 — See all updates

Documents

Cystic fibrosis screening laboratory handbook

HTML

CF laboratory guide pathways: text versions

HTML

Details

The handbook sets out laboratory standards and guidelines for cystic fibrosis (CF) screening in newborn babies, covering:

  • the CF screening protocol
  • laboratory quality and performance
  • pre-analytical factors
  • the immunoreactive trypsinogen (IRT) assay
  • genetic analysis
  • reporting and communication of results
  • programme monitoring and data collection
  • the background to CF screening

The handbook also includes links to screening result template letters, follow up forms, and information for parents/carers.

This publication was previously published by Public Health England, which closed on 30 September 2021.

Updates to this page

Published 1 February 2014

Last updated 205 DecemberJanuary 20242026 + show href="#full-history">+ show all updates

    3. Updated the national cut-off values for the Genetic Screening Processor (GSP) analyser.

Sign up for emails or print this page

Update history

2026-01-05 14:12
Updated cut off for GSP equipment users

2024-12-20 15:28
Updated the national cut-off values for the Genetic Screening Processor (GSP) analyser.

2024-10-08 15:54
Added clarification that publication was previously published by Public Health England. Removed screening helpdesk information.

2022-05-31 10:17
GSP figures in the standard protocol section of the lab handbook have been changed from 45 µg/L to 46 µg/L for cut-off A, and 55 µg/L to 56 µg/L for cut-off B. The accompanying flowchart (figure 1) has been updated to reflect these changes.